Study of Frontal Alpha Asymmetry in Mild Depression: A Potential Biomarker or Not?
Identifieur interne : 000419 ( Main/Exploration ); précédent : 000418; suivant : 000420Study of Frontal Alpha Asymmetry in Mild Depression: A Potential Biomarker or Not?
Auteurs : Ambrish S. Dharmadhikari [Inde] ; Suyog Vijay Jaiswal [Inde] ; Avinash L. Tandle [Inde] ; Deoraj Sinha [Inde] ; Nandini Jog [Inde]Source :
- Journal of neurosciences in rural practice [ 0976-3147 ]
Abstract
Background
Depression, despite being the most common of mental illness lacks any quantifiable and absolute biomarker. Frontal alpha asymmetry (FAA) is proposed as biomarker of depression both in resting and activated state. Yet, the location of extraction of alpha, clinical utility as well as validity of FAA is uncertain. With aim of obtaining clarity on this confusion we conducted this study.
Methodology
Electroencephalographic frontal alpha power was calculated in patients of depression (
Results
Frontal alpha power was measured across FP1, FP2, F3, F4, F7, and F8. Mean powers were compared in resting (before), activated (during) and postactivated resting stage (after). FAA was statistically significant in F7-F8 pair of electrodes and on F7 electrode when compared between cases and controls.
Conclusion
Quest for biomarker for depression churned out FAA as frontrunner. Despite of vast amount of research on it, practical utility eludes us. We need to revisit our approach from conventional search of the diagnostic biomarker; as FAA might reflect component of depression but not totally disorder. In our opinion, we are not yet ready for it and have a road ahead to travel.
DOI: 10.4103/jnrp.jnrp_293_18
PubMed: 31001013
PubMed Central: PMC6454961
Affiliations:
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T. Medical College and Dr. R. N. Cooper Mun. Gen. Hospital, Mumbai, Maharashtra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Psychiatry, H. B. T. Medical College and Dr. R. N. Cooper Mun. Gen. Hospital, Mumbai, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author><author><name sortKey="Tandle, Avinash L" sort="Tandle, Avinash L" uniqKey="Tandle A" first="Avinash L" last="Tandle">Avinash L. Tandle</name><affiliation wicri:level="1"><nlm:affiliation>Department of Electronics and Telecommunication, Mukesh Patel School of Technology, Management and Engineering, NMIMS University, Mumbai, Maharashtra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Electronics and Telecommunication, Mukesh Patel School of Technology, Management and Engineering, NMIMS University, Mumbai, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author><author><name sortKey="Sinha, Deoraj" sort="Sinha, Deoraj" uniqKey="Sinha D" first="Deoraj" last="Sinha">Deoraj Sinha</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, H. B. T. Medical College and Dr. R. N. Cooper Mun. Gen. Hospital, Mumbai, Maharashtra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Psychiatry, H. B. T. Medical College and Dr. R. N. Cooper Mun. Gen. 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Dharmadhikari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, H. B. T. Medical College and Dr. R. N. Cooper Mun. Gen. Hospital, Mumbai, Maharashtra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Psychiatry, H. B. T. Medical College and Dr. R. N. Cooper Mun. Gen. Hospital, Mumbai, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author><author><name sortKey="Jaiswal, Suyog Vijay" sort="Jaiswal, Suyog Vijay" uniqKey="Jaiswal S" first="Suyog Vijay" last="Jaiswal">Suyog Vijay Jaiswal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, H. B. T. Medical College and Dr. R. N. Cooper Mun. Gen. Hospital, Mumbai, Maharashtra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Psychiatry, H. B. T. Medical College and Dr. R. N. Cooper Mun. Gen. Hospital, Mumbai, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author><author><name sortKey="Tandle, Avinash L" sort="Tandle, Avinash L" uniqKey="Tandle A" first="Avinash L" last="Tandle">Avinash L. Tandle</name><affiliation wicri:level="1"><nlm:affiliation>Department of Electronics and Telecommunication, Mukesh Patel School of Technology, Management and Engineering, NMIMS University, Mumbai, Maharashtra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Electronics and Telecommunication, Mukesh Patel School of Technology, Management and Engineering, NMIMS University, Mumbai, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author><author><name sortKey="Sinha, Deoraj" sort="Sinha, Deoraj" uniqKey="Sinha D" first="Deoraj" last="Sinha">Deoraj Sinha</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, H. B. T. Medical College and Dr. R. N. Cooper Mun. Gen. Hospital, Mumbai, Maharashtra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Psychiatry, H. B. T. Medical College and Dr. R. N. Cooper Mun. Gen. Hospital, Mumbai, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author><author><name sortKey="Jog, Nandini" sort="Jog, Nandini" uniqKey="Jog N" first="Nandini" last="Jog">Nandini Jog</name><affiliation wicri:level="1"><nlm:affiliation>Department of Electronics and Telecommunication, Mukesh Patel School of Technology, Management and Engineering, NMIMS University, Mumbai, Maharashtra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Electronics and Telecommunication, Mukesh Patel School of Technology, Management and Engineering, NMIMS University, Mumbai, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of neurosciences in rural practice</title><idno type="ISSN">0976-3147</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Background</b></p><p>Depression, despite being the most common of mental illness lacks any quantifiable and absolute biomarker. Frontal alpha asymmetry (FAA) is proposed as biomarker of depression both in resting and activated state. Yet, the location of extraction of alpha, clinical utility as well as validity of FAA is uncertain. With aim of obtaining clarity on this confusion we conducted this study.</p></div><div type="abstract" xml:lang="en"><p><b>Methodology</b></p><p>Electroencephalographic frontal alpha power was calculated in patients of depression (</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>Frontal alpha power was measured across FP1, FP2, F3, F4, F7, and F8. Mean powers were compared in resting (before), activated (during) and postactivated resting stage (after). FAA was statistically significant in F7-F8 pair of electrodes and on F7 electrode when compared between cases and controls.</p></div><div type="abstract" xml:lang="en"><p><b>Conclusion</b></p><p>Quest for biomarker for depression churned out FAA as frontrunner. Despite of vast amount of research on it, practical utility eludes us. We need to revisit our approach from conventional search of the diagnostic biomarker; as FAA might reflect component of depression but not totally disorder. In our opinion, we are not yet ready for it and have a road ahead to travel.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">31001013</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>29</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0976-3147</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>2</Issue><PubDate><MedlineDate>2019 Apr-Jun</MedlineDate></PubDate></JournalIssue><Title>Journal of neurosciences in rural practice</Title><ISOAbbreviation>J Neurosci Rural Pract</ISOAbbreviation></Journal><ArticleTitle>Study of Frontal Alpha Asymmetry in Mild Depression: A Potential Biomarker or Not?</ArticleTitle><Pagination><MedlinePgn>250-255</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4103/jnrp.jnrp_293_18</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Depression, despite being the most common of mental illness lacks any quantifiable and absolute biomarker. Frontal alpha asymmetry (FAA) is proposed as biomarker of depression both in resting and activated state. Yet, the location of extraction of alpha, clinical utility as well as validity of FAA is uncertain. With aim of obtaining clarity on this confusion we conducted this study.</AbstractText><AbstractText Label="Methodology" NlmCategory="UNASSIGNED">Electroencephalographic frontal alpha power was calculated in patients of depression (<i>n</i> = 24) and compared with healthy controls (<i>n</i> = 17) for the assessment of FAA. Both groups were studied for resting phase and activation phase changes in FAA. For activation phase, auditory stimuli in the form of Indian classical music were used.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">Frontal alpha power was measured across FP1, FP2, F3, F4, F7, and F8. Mean powers were compared in resting (before), activated (during) and postactivated resting stage (after). FAA was statistically significant in F7-F8 pair of electrodes and on F7 electrode when compared between cases and controls.</AbstractText><AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">Quest for biomarker for depression churned out FAA as frontrunner. Despite of vast amount of research on it, practical utility eludes us. We need to revisit our approach from conventional search of the diagnostic biomarker; as FAA might reflect component of depression but not totally disorder. In our opinion, we are not yet ready for it and have a road ahead to travel.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dharmadhikari</LastName><ForeName>Ambrish S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, H. B. T. Medical College and Dr. R. N. Cooper Mun. Gen. Hospital, Mumbai, Maharashtra, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jaiswal</LastName><ForeName>Suyog Vijay</ForeName><Initials>SV</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, H. B. T. Medical College and Dr. R. N. Cooper Mun. Gen. Hospital, Mumbai, Maharashtra, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tandle</LastName><ForeName>Avinash L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Electronics and Telecommunication, Mukesh Patel School of Technology, Management and Engineering, NMIMS University, Mumbai, Maharashtra, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sinha</LastName><ForeName>Deoraj</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, H. B. T. Medical College and Dr. R. N. Cooper Mun. Gen. Hospital, Mumbai, Maharashtra, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jog</LastName><ForeName>Nandini</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Electronics and Telecommunication, Mukesh Patel School of Technology, Management and Engineering, NMIMS University, Mumbai, Maharashtra, India.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Neurosci Rural Pract</MedlineTA><NlmUniqueID>101533710</NlmUniqueID><ISSNLinking>0976-3155</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Alpha rhythm</Keyword><Keyword MajorTopicYN="N">biomarker</Keyword><Keyword MajorTopicYN="N">depressive disorder</Keyword><Keyword MajorTopicYN="N">electroencephalography</Keyword><Keyword MajorTopicYN="N">frontal alpha asymmetry</Keyword></KeywordList><CoiStatement>There are no conflicts of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31001013</ArticleId><ArticleId IdType="doi">10.4103/jnrp.jnrp_293_18</ArticleId><ArticleId IdType="pii">JNRP-10-250</ArticleId><ArticleId IdType="pmc">PMC6454961</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>JAMA. 1999 Aug 25;282(8):786-90</Citation><ArticleIdList><ArticleId IdType="pubmed">10463718</ArticleId></ArticleIdList></Reference><Reference><Citation>Control Clin Trials. 2001 Oct;22(5):485-502</Citation><ArticleIdList><ArticleId IdType="pubmed">11578783</ArticleId></ArticleIdList></Reference><Reference><Citation>Biol Psychiatry. 2002 Jul 15;52(2):73-85</Citation><ArticleIdList><ArticleId IdType="pubmed">12113998</ArticleId></ArticleIdList></Reference><Reference><Citation>J Abnorm Psychol. 2004 May;113(2):324-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15122952</ArticleId></ArticleIdList></Reference><Reference><Citation>Biol Psychol. 2004 Oct;67(1-2):183-218</Citation><ArticleIdList><ArticleId IdType="pubmed">15130531</ArticleId></ArticleIdList></Reference><Reference><Citation>J Abnorm Psychol. 2006 Nov;115(4):715-29</Citation><ArticleIdList><ArticleId IdType="pubmed">17100529</ArticleId></ArticleIdList></Reference><Reference><Citation>Psychophysiology. 2011 Jan;48(1):82-95</Citation><ArticleIdList><ArticleId IdType="pubmed">20525011</ArticleId></ArticleIdList></Reference><Reference><Citation>J Abnorm Psychol. 2010 Aug;119(3):502-12</Citation><ArticleIdList><ArticleId IdType="pubmed">20677839</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Pharmacol. 2011 Jun 15;81(12):1408-21</Citation><ArticleIdList><ArticleId IdType="pubmed">20937262</ArticleId></ArticleIdList></Reference><Reference><Citation>Neuropsychopharmacology. 2011 Nov;36(12):2375-94</Citation><ArticleIdList><ArticleId IdType="pubmed">21814182</ArticleId></ArticleIdList></Reference><Reference><Citation>Neuropharmacology. 2012 Sep;63(4):507-13</Citation><ArticleIdList><ArticleId IdType="pubmed">22569197</ArticleId></ArticleIdList></Reference><Reference><Citation>Brain Topogr. 2013 Apr;26(2):338-54</Citation><ArticleIdList><ArticleId IdType="pubmed">22983820</ArticleId></ArticleIdList></Reference><Reference><Citation>Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:102-11</Citation><ArticleIdList><ArticleId IdType="pubmed">24104186</ArticleId></ArticleIdList></Reference><Reference><Citation>Int Rev Psychiatry. 2013 Oct;25(5):604-18</Citation><ArticleIdList><ArticleId IdType="pubmed">24151805</ArticleId></ArticleIdList></Reference><Reference><Citation>Psychophysiology. 2014 May;51(5):446-55</Citation><ArticleIdList><ArticleId IdType="pubmed">24611480</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2015 Feb 06;10(2):e0116820</Citation><ArticleIdList><ArticleId IdType="pubmed">25658103</ArticleId></ArticleIdList></Reference><Reference><Citation>Behav Brain Res. 2015 Oct 1;292:56-67</Citation><ArticleIdList><ArticleId IdType="pubmed">26051816</ArticleId></ArticleIdList></Reference><Reference><Citation>Neurosci Biobehav Rev. 2015 Dec;59:1-15</Citation><ArticleIdList><ArticleId IdType="pubmed">26432926</ArticleId></ArticleIdList></Reference><Reference><Citation>Neuroimage Clin. 2016 Feb 12;11:224-238</Citation><ArticleIdList><ArticleId IdType="pubmed">26958462</ArticleId></ArticleIdList></Reference><Reference><Citation>Neuroimage Clin. 2017 Jul 15;16:79-87</Citation><ArticleIdList><ArticleId IdType="pubmed">28761811</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Hum Neurosci. 2017 Dec 04;11:584</Citation><ArticleIdList><ArticleId IdType="pubmed">29255409</ArticleId></ArticleIdList></Reference><Reference><Citation>East Asian Arch Psychiatry. 2018 Mar;28(1):17-22</Citation><ArticleIdList><ArticleId IdType="pubmed">29576552</ArticleId></ArticleIdList></Reference><Reference><Citation>Brain Cogn. 1987 Apr;6(2):175-83</Citation><ArticleIdList><ArticleId IdType="pubmed">3593557</ArticleId></ArticleIdList></Reference><Reference><Citation>Biol Psychiatry. 1997 May 1;41(9):939-48</Citation><ArticleIdList><ArticleId IdType="pubmed">9110099</ArticleId></ArticleIdList></Reference><Reference><Citation>Psychophysiology. 1998 Jul;35(4):389-404</Citation><ArticleIdList><ArticleId IdType="pubmed">9643053</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Dharmadhikari, Ambrish S" sort="Dharmadhikari, Ambrish S" uniqKey="Dharmadhikari A" first="Ambrish S" last="Dharmadhikari">Ambrish S. Dharmadhikari</name></noRegion><name sortKey="Jaiswal, Suyog Vijay" sort="Jaiswal, Suyog Vijay" uniqKey="Jaiswal S" first="Suyog Vijay" last="Jaiswal">Suyog Vijay Jaiswal</name><name sortKey="Jog, Nandini" sort="Jog, Nandini" uniqKey="Jog N" first="Nandini" last="Jog">Nandini Jog</name><name sortKey="Sinha, Deoraj" sort="Sinha, Deoraj" uniqKey="Sinha D" first="Deoraj" last="Sinha">Deoraj Sinha</name><name sortKey="Tandle, Avinash L" sort="Tandle, Avinash L" uniqKey="Tandle A" first="Avinash L" last="Tandle">Avinash L. Tandle</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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